ABSTRACT
Minor aphta has a high incidence in the populations ranging from 2-50%. In spite of its frequency and severity of discomfort, there is not an absolute treatment for it. So, the main objective of this study was to evaluate the efficacy of a herbal medicine in the control of Minor aphta. In this double-blind, randomized study 137 patients with Minor aphta [with not more than four days from the onset] were selected and then placed into one of the groups of A [solution containing 5 percent Myrtus communis and Melissa officinalis in ethanol 80] and B [solution containing 10 percent Myrtus communis and Melissa officinalis in ethanol 80] or C [placebo containing ethanol 80]. Mean duration for complete recovery in minor aphta was 3.5 days in group A, 7.5 days in group B and 7.3 days in group C. There significant statistical differences the three groups [p<0.0005]. The results of this study revealed that using a combination of Myrtus Communis and Melissa Officinalis plants was effective in the treatment of recurrent aphtous stomatits [RAS]. In order to obtain the accurate concentrations of the ingredients of this compound, further studies are necessary